Atherosclerosis 动脉粥样硬化

Atherosclerosis is a common disorder of the arteries. Fat, cholesterol and other substances accumulate in the walls of the arteries and form “atheromas” or plaque. Oxidation of these substances contribute to the accumulation.

Eventually, this fatty tissue can erode the wall of the artery, diminish its elasticity and interfere with blood flow. Plaques can also rupture/break off, causing debris to migrate downstream within an artery. This is a common cause of heart attack and stroke.

Clots can also form around the plaque deposits, further interfering with blood flow and posing additional danger if they break off and travel to the heart, lungs and brain. Many doctors now suspect that people with a high inflammation risk are at risk from atherosclerosis.

Risk factors for atherosclerosis include: smoking, high blood pressure, excessive dietary fats, poor blood cholesterol levels, diabetes, cerebrovascular disease, peripheral vascular disease, and kidney disease.

Applied nutrition

See “heart attack / stroke”. The theme is to reduce inflammatory risk, increase anti-oxidative nutritional intake, reduce fat and cholesterol and slowly increase exercise levels.

Heart Disease 心脏病

A heart attack occurs when an area of heart muscle dies or is permanently damaged because of inadequate oxygen supply.

A stroke or “brain attack” occurs when blood supply to the brain is interrupted and brain tissue dies. Victims can suffer from lifelong disabilities, speech difficulties, paralysis and even death.

Possible causes

Most heart attacks are caused by a blood clot that blocks one of the coronary arteries (blood vessels that bring blood and oxygen to the heart muscle). The clot usually forms in a coronary artery that has been narrowed due to atherosclerosis (inflammation and/or cholesterol buildup).

A clot in the coronary artery interrupts the flow of blood and oxygen to the heart muscle, leading to the death of heart cells in that area. The damaged heart muscle loses its ability to contract and the remaining heart muscle needs to work hard to compensate for that weakened area. This overwhelming stress can trigger a heart attack.

Risk factors for coronary artery disease and heart attack include: smoking, high blood pressure, excessive dietary fats, poor blood cholesterol levels, diabetes, being male, being over 40 and heredity.

In many cases, the pain may be subtle or even completely absent (silent heart attack), especially in the elderly and those with diabetes. Often the pain radiates from the chest to the arms, shoulders, neck, jaw, abdomen and back.

The pain typically lasts for over 20 minutes and is not fully relieved by rest. Other symptoms include: shortness of breath; coughing; dizziness; fainting; nausea/vomiting; sweating; and a feeling of impending doom.

Applied nutrition

Supplement Benefit Suggested Dosage
Protein Essential amino acids help repair body tissues 1 scoop,
3x daily
CoQ10 Improves heart muscle oxygenation and ,may help prevent heart attacks and follow-on attacks 2 tabs,
2x daily
Omega 3 Important for circulation and lowering blood pressure. Protects heart muscle cells and reduces tryglyceride levels in the blood 2 tabs,
3x daily
Garlic + licorice Beneficial for the heart, promotes circulation and effective in reducing high blood pressure 2 tabs,
3x daily
B Complex Important for circulatory function and lowering blood pressure. B6 reduces water content in tissues to relieve pressure on the cardiovascular system 3 tabs,
3x daily
Calcium + magnesium Deficiencies have been linked to high blood pressure. If taking high blood pressure drugs, take extra potassium to counteract depletion of calcium. Important for maintaining proper heart rhythm and blood pressure 2 tabs,
3x daily
Vitamin C + bioflavonoids Improves adrenal function, reduces blood-clotting tendencies 3 tabs,
3x daily
Lecithin E Powerful antioxidants that improve circulation and thins the blood, reducing clotting risk. Lecithin also reduces plaque buildup in the blood vessels 3 tabs,
3x daily
Ginkgo biloba + ginseng Improves circulation 2 tabs,
2x daily
Green tea extract Lowers cholesterol and lipid levels As indicated

Cholesterol

Cholesterol is a soft, waxy substance found in all parts of the body. It is made by the body and also obtained from animal products in the diet.

Lipid disorders occur when one has excessive fatty substances in the blood. These substances include cholesterol and triglycerides. Having a lipid disorder makes one more likely to develop atherosclerosis and heart disease.

Functions

HDL is used to make bile, which helps in transporting fat and liver detoxification. This friendly scavenger also cruises the bloodstream. As it does, it removes harmful bad cholesterol from where it doesn’t belong. High HDL levels reduce the risk for heart disease — but low levels increase the risk.

LDL collects in the walls of your blood vessels, where it can cause blockages. Higher LDL levels put you at greater risk for a heart attack from a sudden blood clot that forms there.

Triglycerides are a type of fat (lipid) found in your blood. When you eat, your body converts any calories it doesn’t need to use right away into triglycerides. The triglycerides are stored in your fat cells. Later, hormones release triglycerides for energy between meals. If you regularly eat more calories than you burn, particularly “easy” calories like carbohydrates and fats, you may have high triglycerides (hypertriglyceridemia).

Possible causes

Cholesterol can be bound to fat at different densities. Two main types are:

  • Low-density lipoproteins – LDL – bad cholesterol, to be kept low.
  • High-density lipoproteins – HDL – good cholesterol, to be kept high.

High bad cholesterol and other lipid disorders can be associated with:
fatty diets; diabetes; hypothyroidism; Cushing’s syndrome and kidney failure; certain medication including birth control pills, estrogen, corticosteroids, certain diuretics and beta-blockers; lifestyle factors including excessive alcohol consumption and lack of exercise leading to obesity.

People who smoke and also have high cholesterol are at even greater risk since the cholesterol in the blood are rapidly hardened through oxidation.

Cholesterol levels

Good Borderline Caution
Total Cholesterol < 200 200 – 239 240+
HDL > 45 35 – 44 < 35
LDL < 130 130 – 159 160+
Ratio ≤ 3.4 5.5 – 7.4 ≥ 7.5
Triglycerides < 200 200 – 399 400+

Applied nutrition

Recommend to reduce fat intake, trans-fat intake, high-heat treated oils and fats. Increase deep sea fish intake (caution on tuna), increase fiber intake, lose weight and increase physical activity.

Supplement Benefit Suggested Dosage
Protein Supplies balanced amounts of nine essential amino acids 1 scoop,
3x daily
Coenzyme Q10 Improves heart muscle oxygenation and may help prevent heart attacks. 2 tabs,
2x daily
Omega 3 Important for circulation and lowering blood pressure. Protects heart muscle cells and reduces triglycerides level in the blood. Thins the blood. 2 tabs,
3x daily
Garlic + licorice Beneficial for the heart, promotes circulation and effective in reducing blood pressure. 2 tabs,
3x daily
Calcium + magnesium Deficiencies have been linked to high blood pressure. If taking high blood pressure medication, take extra potassium to counteract the depletion of calcium. Important for maintaining proper heart rhythm and blood pressure. 2 tabs,
3x daily
Fiber Bulk forming and increases water content of stool, detoxifying the colon and cleansing the breath. 3 tabs,
3x daily
B Complex Important for circulation function and lowering blood pressure. B6 reduces water in tissues to relieve pressure on the cardiovascular system. 3 tabs,
3x daily
Vitamin E + lecithin Powerful antioxidants that improve circulation and thins the blood, reducing clotting risk. Lecithin also aids in blood-thinning. 3 tabs,
3x daily
Vitamin C + bioflavonoids Powerful free radical destroyer and anti-inflammatory agent. Bioflavonoids enhance the activity of vitamin C. 3 tabs,
3x daily
Green tea extract Delivers catechins and theaflavins in synergy with phytonutrients to help maintain healthy cholesterol levels. 2 tabs,
2x daily

 

Pantothenic acid (Vitamin B5)

Vitamin B5, also called pantothenic acid, is one of 8 B vitamins. All B vitamins help the body convert carbohydrates into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body use fats and protein. B complex vitamins are needed for healthy skin, hair, eyes, and liver. They also help the nervous system function properly.

All B vitamins are water-soluble, meaning that the body does not store them and must be replenished daily.

In addition to playing a role in the breakdown of fats and carbohydrates for energy, vitamin B5 is critical to the manufacture of red blood cells, as well as sex and stress-related hormones produced in the adrenal glands atop the kidneys. Vitamin B5 is also important in maintaining a healthy digestive tract, and it helps the body use other vitamins, particularly B2 or riboflavin. It is sometimes called the “anti-stress” vitamin.

Your body needs pantothenic acid to synthesize cholesterol.

It is rare for anyone to be seriously deficient in vitamin B5. Symptoms of a vitamin B5 deficiency include fatigue, insomnia, depression, irritability, vomiting, stomach pains, burning feet, and upper respiratory infections.

High Cholesterol/High Triglycerides

Several small, double-blind studies suggest that pantethine may help reduce triglycerides, or fats, in the blood in people who have high cholesterol. In some of these studies, pantethine has also helped lower LDL (bad) cholesterol and raise HDL (good) cholesterol. In some open studies, pantethine seems to lower levels of cholesterol and triglycerides in people with diabetes.

Wound Healing

Studies, mostly in test tubes and animals but a few on people, suggest that vitamin B5 supplements may speed wound healing, especially following surgery. This may be particularly true if vitamin B5 is combined with vitamin C.

Rheumatoid Arthritis

Some early evidence suggests that pantothenic acid might help with symptoms of rheumatoid arthritis (RA). One study found that people with RA may have lower levels of B5 in their blood than healthy people, and the lowest levels were associated with the most severe symptoms. A small study conducted in 1980 concluded that 2,000 mg/day of calcium pantothenate improved symptoms of RA, including morning stiffness and pain.

Dietary Sources

Pantothenic acid gets its name from the Greek root pantos, meaning “everywhere,” because it is available in a wide variety of foods. A lot of vitamin B5 is lost when you food is processed, however. Fresh meats, vegetables, and whole unprocessed grains have more vitamin B5 than refined, canned, and frozen food. The best sources are brewer’s yeast, corn, cauliflower, kale, broccoli, tomatoes, avocado, legumes, lentils, egg yolks, beef (especially organ meats such as liver and kidney), turkey, duck, chicken, milk, split peas, peanuts, soybeans, sweet potatoes, sunflower seeds, whole-grain breads and cereals, lobster, wheat germ, and salmon.

Upper Limits

The Council for Responsible Nutrition recommends an upper limit of 1,000 mg / day for pantothenic acid, citing the lack of adverse effects with daily intakes as high as 10  g.

Source

University of Maryland Medical Center